Reaction Details Report a problem with these data
Target
Lysophosphatidylserine lipase ABHD12
Ligand
BDBM50526072
Substrate
n/a
Meas. Tech.
ChEMBL_1899078 (CHEMBL4401193)
IC50
320±n/a nM
Citation
 Ogasawara, D; Ichu, TA; Jing, H; Hulce, JJ; Reed, A; Ulanovskaya, OA; Cravatt, BF Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase ?/?-Hydrolase Domain-Containing 12 (ABHD12). J Med Chem 62:1643-1656 (2019) [PubMed]  Article 
Target
Name:
Lysophosphatidylserine lipase ABHD12
Synonyms:
ABD12_MOUSE | Abhd12 | Monoacylglycerol lipase ABHD12
Type:
PROTEIN
Mol. Mass.:
45284.87
Organism:
Mus musculus
Description:
ChEMBL_643596
Residue:
398
Sequence:
MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
  
Inhibitor
Name:
BDBM50526072
Synonyms:
CHEMBL4590567
Type:
Small organic molecule
Emp. Form.:
C31H31N5O7
Mol. Mass.:
585.6071
SMILES:
COc1ccc(cc1)N1CCN(CC1)C(=O)ON1C(=O)C2CN(CCN2C1=O)C(=O)c1ccc(Oc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: