Reaction Details Report a problem with these data
Target
Lysophosphatidylserine lipase ABHD12
Ligand
BDBM50526099
Substrate
n/a
Meas. Tech.
ChEMBL_1899079 (CHEMBL4401194)
IC50
96±n/a nM
Citation
 Ogasawara, D; Ichu, TA; Jing, H; Hulce, JJ; Reed, A; Ulanovskaya, OA; Cravatt, BF Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase ?/?-Hydrolase Domain-Containing 12 (ABHD12). J Med Chem 62:1643-1656 (2019) [PubMed]  Article 
Target
Name:
Lysophosphatidylserine lipase ABHD12
Synonyms:
ABD12_MOUSE | Abhd12 | Monoacylglycerol lipase ABHD12
Type:
PROTEIN
Mol. Mass.:
45284.87
Organism:
Mus musculus
Description:
ChEMBL_643596
Residue:
398
Sequence:
MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
  
Inhibitor
Name:
BDBM50526099
Synonyms:
CHEMBL4587861
Type:
Small organic molecule
Emp. Form.:
C23H21ClF3N5O2S
Mol. Mass.:
523.958
SMILES:
FC(F)(F)Oc1ccccc1Oc1ccnc(N2CCC(CC2)NC(=S)Nc2cccnc2)c1Cl
Structure:
Search PDB for entries with ligand similarity: