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Target
Relaxin-3 receptor 2
Ligand
BDBM50526407
Substrate
n/a
Meas. Tech.
ChEMBL_1899973 (CHEMBL4402088)
EC50
4.0±n/a nM
Citation
 DeChristopher, B; Park, SH; Vong, L; Bamford, D; Cho, HH; Duvadie, R; Fedolak, A; Hogan, C; Honda, T; Pandey, P; Rozhitskaya, O; Su, L; Tomlinson, E; Wallace, I Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration. Bioorg Med Chem Lett 29:991-994 (2019) [PubMed]  Article 
Target
Name:
Relaxin-3 receptor 2
Synonyms:
G-protein coupled receptor 100 | G-protein coupled receptor GPCR142 | GPCR142 | GPR100 | Insulin-like peptide INSL5 receptor | RL3R2_HUMAN | RLN3 receptor 2 | RLN3R2 | RXFP4 | Relaxin family peptide receptor 4
Type:
PROTEIN
Mol. Mass.:
41161.14
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456194
Residue:
374
Sequence:
MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG
  
Inhibitor
Name:
BDBM50526407
Synonyms:
CHEMBL4470544
Type:
Small organic molecule
Emp. Form.:
C19H19Cl2N5O
Mol. Mass.:
404.293
SMILES:
Cc1cc(O)cc2c(\C=N\NC(=N)NCCc3ccc(Cl)c(Cl)c3)c[nH]c12
Structure:
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