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Target
Cyclic nucleotide-gated olfactory channel
Ligand
BDBM81289
Substrate
n/a
Meas. Tech.
ChEMBL_1900214 (CHEMBL4402329)
EC50
53100±n/a nM
Citation
 Lelle, M; Otte, M; Thon, S; Bertinetti, D; Herberg, FW; Benndorf, K Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives. Bioorg Med Chem 27:1704-1713 (2019) [PubMed]  Article 
Target
Name:
Cyclic nucleotide-gated olfactory channel
Synonyms:
CNG channel alpha-2 | CNG-2 | CNG2 | CNGA2_RAT | Cncg2 | Cnga2 | Cyclic nucleotide-gated cation channel 2 | Cyclic nucleotide-gated channel alpha-2 | Cyclic nucleotide-gated olfactory channel | Cyclic nucleotide-gated olfactory channel subunit OCNC1
Type:
PROTEIN
Mol. Mass.:
76176.63
Organism:
Rattus norvegicus
Description:
ChEMBL_119374
Residue:
664
Sequence:
MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSPELQRLAEMDTPRRGRGGFQRIVRLVGVIRDWANKNFREEEPRPDSFLERFRGPELQTVTTHQGDDKGGKDGEGKGTKKKFELFVLDPAGDWYYRWLFVIAMPVLYNWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLVLYILVIIHWNACIYYVISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVAASMEVDVQEKLEQLETNMDTLYTRFARLLAEYTGAQQKLKQRITVLETKMKQNHEDDYLSDGINTPEPTAAE
  
Inhibitor
Name:
BDBM81289
Synonyms:
Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate | MLS001333136 | SMR000875274 | cid_23669773 | sodium;(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-oxidanidyl-2-oxidanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol | sodium;(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol | sodium;(4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-7-ol | sodium;(4aR,6R,7R,7aS)-6-adenin-9-yl-2-keto-2-oxido-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphorin-7-ol
Type:
Small organic molecule
Emp. Form.:
C10H11N5O6P
Mol. Mass.:
328.1986
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O
Structure:
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