Reaction Details Report a problem with these data
Target
Rap guanine nucleotide exchange factor 4
Ligand
BDBM50526579
Substrate
n/a
Meas. Tech.
ChEMBL_1900219 (CHEMBL4402334)
EC50
2360±n/a nM
Citation
 Lelle, M; Otte, M; Thon, S; Bertinetti, D; Herberg, FW; Benndorf, K Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives. Bioorg Med Chem 27:1704-1713 (2019) [PubMed]  Article 
Target
Name:
Rap guanine nucleotide exchange factor 4
Synonyms:
Cgef2 | Cgef2 | EPAC 2 | Epac2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RPGF4_MOUSE | Rap guanine nucleotide exchange factor 4 | Rapgef4 | cAMP-GEFII | cAMP-dependent Rap1 guanine-nucleotide exchange factor | cAMP-regulated guanine nucleotide exchange factor II
Type:
PROTEIN
Mol. Mass.:
115497.71
Organism:
Mus musculus
Description:
ChEMBL_109832
Residue:
1011
Sequence:
MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
  
Inhibitor
Name:
BDBM50526579
Synonyms:
CHEMBL4442766
Type:
Small organic molecule
Emp. Form.:
C11H11BrN4NaO6P
Mol. Mass.:
429.096
SMILES:
[Na;v0+].[H][C@@]12[#6]-[#8]P([#8-])(=O)[#8][C@@]1([H])[#6@@H](-[#8])-[#6@@H](-[#8]2)-n1cc(Br)c2c(-[#7])ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: