Reaction Details Report a problem with these data
Target
Cyclic nucleotide-gated olfactory channel
Ligand
BDBM50526579
Substrate
n/a
Meas. Tech.
ChEMBL_1900214 (CHEMBL4402329)
EC50
540±n/a nM
Citation
 Lelle, M; Otte, M; Thon, S; Bertinetti, D; Herberg, FW; Benndorf, K Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives. Bioorg Med Chem 27:1704-1713 (2019) [PubMed]  Article 
Target
Name:
Cyclic nucleotide-gated olfactory channel
Synonyms:
CNG channel alpha-2 | CNG-2 | CNG2 | CNGA2_RAT | Cncg2 | Cnga2 | Cyclic nucleotide-gated cation channel 2 | Cyclic nucleotide-gated channel alpha-2 | Cyclic nucleotide-gated olfactory channel | Cyclic nucleotide-gated olfactory channel subunit OCNC1
Type:
PROTEIN
Mol. Mass.:
76176.63
Organism:
Rattus norvegicus
Description:
ChEMBL_119374
Residue:
664
Sequence:
MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSPELQRLAEMDTPRRGRGGFQRIVRLVGVIRDWANKNFREEEPRPDSFLERFRGPELQTVTTHQGDDKGGKDGEGKGTKKKFELFVLDPAGDWYYRWLFVIAMPVLYNWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLVLYILVIIHWNACIYYVISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVAASMEVDVQEKLEQLETNMDTLYTRFARLLAEYTGAQQKLKQRITVLETKMKQNHEDDYLSDGINTPEPTAAE
  
Inhibitor
Name:
BDBM50526579
Synonyms:
CHEMBL4442766
Type:
Small organic molecule
Emp. Form.:
C11H11BrN4NaO6P
Mol. Mass.:
429.096
SMILES:
[Na;v0+].[H][C@@]12[#6]-[#8]P([#8-])(=O)[#8][C@@]1([H])[#6@@H](-[#8])-[#6@@H](-[#8]2)-n1cc(Br)c2c(-[#7])ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: