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Target
Aminodeoxyfutalosine synthase
Ligand
BDBM50526601
Substrate
n/a
Meas. Tech.
ChEMBL_1900272 (CHEMBL4402387)
IC50
38700±n/a nM
Citation
 Joshi, S; Fedoseyenko, D; Mahanta, N; Ducati, RG; Feng, M; Schramm, VL; Begley, TP Antibacterial Strategy against  ACS Med Chem Lett 10:363-366 (2019) [PubMed]  Article 
Target
Name:
Aminodeoxyfutalosine synthase
Synonyms:
2.5.1.120 | AFL synthase | Aminodeoxyfutalosine synthase | Aminofutalosine synthase | MQNE_THET8 | Menaquinone biosynthetic enzyme MqnE | mqnE
Type:
PROTEIN
Mol. Mass.:
42621.64
Organism:
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Description:
ChEMBL_119077
Residue:
372
Sequence:
MRGIRDPRLIPIAEKVMEGKRLSFEDGLVLYQTKDLPTLMRLANLVRERKHGHKTYFVHSIRVSQTNICYVGCTFCAFQRRFGEEGAWDWDVDEVVAWVKERYQPGLTEIHLTAGHHPKRPFAYYLDLVRALKENFPGVQVKAWTAAEIHHFSKIARLPYREVLKALKEAGLDAMPGGGAEIFAERVRRKIARAKVSAEGWLEIHRTAHELGIPTNATMLYGHIETLEERLDHMDRLRRLQDETGGFMSFIPLAFQPDGNQLARELGKKEFTTGLDDLRNLAVARLYLDNFPHIKGYWATLTPELAQVSLDWGVTDVDGTLIEERIVHMAGSPTPQGLTKRELARIILMAGRIPVERDALYREVRVWDRVEA
  
Inhibitor
Name:
BDBM50526601
Synonyms:
CHEMBL4461488
Type:
Small organic molecule
Emp. Form.:
C11H10O4
Mol. Mass.:
206.1947
SMILES:
OC(=O)C(=C)Cc1cccc(c1)C(O)=O
Structure:
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