Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50526631
Substrate
n/a
Meas. Tech.
ChEMBL_1900460 (CHEMBL4402682)
IC50
5000±n/a nM
Citation
Patel, B; Ryan, P; Makwana, V; Zunk, M; Rudrawar, S; Grant, G Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY. Eur J Med Chem 171:462-474 (2019) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX
Type:
PROTEIN
Mol. Mass.:
39889.38
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_1454117
Residue:
360
Sequence:
MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
Inhibitor
Name:
BDBM50526631
Synonyms:
CHEMBL277069
Type:
Small organic molecule
Emp. Form.:
C15H23N3O10
Mol. Mass.:
405.3572
SMILES:
[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O)[C@H](CO)O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1O
Structure:
