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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50526692
Substrate
n/a
Meas. Tech.
ChEMBL_1900682 (CHEMBL4402904)
Ki
146±n/a nM
Citation
 Yueh, C; Rettenmaier, J; Xia, B; Hall, DR; Alekseenko, A; Porter, KA; Barkovich, K; Keseru, G; Whitty, A; Wells, JA; Vajda, S; Kozakov, D Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases. J Med Chem 62:6512-6524 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50526692
Synonyms:
CHEMBL1230881
Type:
Small organic molecule
Emp. Form.:
C22H22N4O4
Mol. Mass.:
406.4345
SMILES:
CC(C)(C)c1ccc(cc1[N+]([O-])=O)C(=O)NNC(=O)Nc1cccc2ccccc12
Structure:
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