Reaction Details Report a problem with these data
Target
Tyrosine--tRNA ligase, cytoplasmic
Ligand
BDBM50081838
Substrate
n/a
Meas. Tech.
ChEBML_211021
IC50
510±n/a nM
Citation
 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex. Bioorg Med Chem Lett 9:2859-62 (1999) [PubMed]  Article 
Target
Name:
Tyrosine--tRNA ligase, cytoplasmic
Synonyms:
SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1
Type:
PROTEIN
Mol. Mass.:
59145.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211030
Residue:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
  
Inhibitor
Name:
BDBM50081838
Synonyms:
CHEMBL318019 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(2,3,4-trihydroxy-phenyl)-acetic acid
Type:
Small organic molecule
Emp. Form.:
C17H18N2O7
Mol. Mass.:
362.334
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(O)=O)c1ccc(O)c(O)c1O
Structure:
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