Reaction Details Report a problem with these data
Target
Tyrosine--tRNA ligase, cytoplasmic
Ligand
BDBM50081840
Substrate
n/a
Meas. Tech.
ChEBML_211021
IC50
3800±n/a nM
Citation
 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex. Bioorg Med Chem Lett 9:2859-62 (1999) [PubMed]  Article 
Target
Name:
Tyrosine--tRNA ligase, cytoplasmic
Synonyms:
SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1
Type:
PROTEIN
Mol. Mass.:
59145.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211030
Residue:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
  
Inhibitor
Name:
BDBM50081840
Synonyms:
(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionic acid | CHEMBL95286 | Tyr-Tyr
Type:
Small organic molecule
Emp. Form.:
C18H20N2O5
Mol. Mass.:
344.3618
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Structure:
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