Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50082041
Substrate
n/a
Meas. Tech.
ChEMBL_196757 (CHEMBL800546)
EC50
294±n/a nM
Citation
 Zacheis, D; Dhar, A; Lu, S; Madler, MM; Klucik, J; Brown, CW; Liu, S; Clement, F; Subramanian, S; Weerasekare, GM; Berlin, KD; Gold, MA; Houck, JR; Fountain, KR; Benbrook, DM Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem 42:4434-45 (1999) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nr2b1 | RXRA_MOUSE | Retinoid X receptor alpha | Rxra
Type:
PROTEIN
Mol. Mass.:
51225.80
Organism:
Mus musculus
Description:
ChEMBL_196493
Residue:
467
Sequence:
MDTKHFLPLDFSTQVNSSSLNSPTGRGSMAVPSLHPSLGPGIGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQAT
  
Inhibitor
Name:
BDBM50082041
Synonyms:
4-iminomethylphenyl 4,4-dimethyl-6-chromanecarboxylate,urea | CHEMBL341704
Type:
Small organic molecule
Emp. Form.:
C20H21N3O3S
Mol. Mass.:
383.464
SMILES:
CC1(C)CCOc2ccc(cc12)C(=O)Oc1ccc(C=NNC(N)=S)cc1 |w:20.22|
Structure:
Search PDB for entries with ligand similarity: