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Target
Lactoylglutathione lyase
Ligand
BDBM50526944
Substrate
n/a
Meas. Tech.
ChEMBL_1901791 (CHEMBL4404013)
Ki
7.0±n/a nM
Citation
 Jin, T; Zhao, L; Wang, HP; Huang, ML; Yue, Y; Lu, C; Zheng, ZB Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50526944
Synonyms:
CHEMBL4450158
Type:
Small organic molecule
Emp. Form.:
C19H22N4O8S
Mol. Mass.:
466.465
SMILES:
N[C@@H](CCC(=O)N[C@@H](CSC(=O)N(O)c1ccc(cc1)C#C)C(=O)NCC(O)=O)C(O)=O |r|
Structure:
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