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Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Ligand
BDBM50527929
Substrate
n/a
Meas. Tech.
ChEMBL_1904112 (CHEMBL4406334)
IC50
9400±n/a nM
Citation
 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Discovery and Structure-Activity Relationship Study of ( J Med Chem 63:4880-4895 (2020) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Synonyms:
PI42B_HUMAN | PIP4K2B | PIP5K2B | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta
Type:
PROTEIN
Mol. Mass.:
47382.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774395
Residue:
416
Sequence:
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
  
Inhibitor
Name:
BDBM50527929
Synonyms:
CHEMBL4455633
Type:
Small organic molecule
Emp. Form.:
C20H17N3O2S
Mol. Mass.:
363.433
SMILES:
CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2[nH]ccc12
Structure:
Search PDB for entries with ligand similarity: