Reaction Details
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Cytochrome P450 4F3
Ligand
BDBM50527963
Substrate
n/a
Meas. Tech.
ChEMBL_1904214 (CHEMBL4406436)
IC50
447000±n/a nM
Citation
Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1. J Med Chem 63:4824-4836 (2020) [PubMed] Article More Info.:
Target
Name:
Cytochrome P450 4F3
Synonyms:
1.14.14.1 | 1.14.14.79 | 1.14.14.94 | 20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | CP4F3_HUMAN | CYP4F3 | CYPIVF3 | Cytochrome P450 4F3 | Cytochrome P450-LTB-omega | Docosahexaenoic acid omega-hydroxylase CYP4F3 | LTB4H | Leukotriene-B(4) 20-monooxygenase 2 | Leukotriene-B(4) omega-hydroxylase 2 | Synonyms=LTB4H
Type:
PROTEIN
Mol. Mass.:
59856.15
Organism:
Homo sapiens
Description:
ChEMBL_119703
Residue:
520
Sequence:
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
Inhibitor
Name:
BDBM50527963
Synonyms:
CHEMBL4557940
Type:
Small organic molecule
Emp. Form.:
C14H20N4O2
Mol. Mass.:
276.3342
SMILES:
OC(=O)CCCCCCCNn1nnc2ccccc12
Structure:
