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Target
D(3) dopamine receptor
Ligand
BDBM50116766
Substrate
n/a
Meas. Tech.
ChEMBL_1904401 (CHEMBL4406623)
Ki
0.900000±n/a nM
Citation
 Moritz, AE; Free, RB; Weiner, WS; Akano, EO; Gandhi, D; Abramyan, A; Keck, TM; Ferrer, M; Hu, X; Southall, N; Steiner, J; Aubé, J; Shi, L; Frankowski, KJ; Sibley, DR Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D J Med Chem 63:5526-5567 (2020) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DRD3_HUMAN | DRD3 | Dopamine D3 receptor (D3R) | Dopamine D3 receptor (D3) | Dopamine D3 receptor | DOPAMINE D3 | Dopamine receptor | Dopamine receptor D3 | Dopamine receptor (D3)
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Human
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50116766
Synonyms:
(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine | CHEMBL301265 | (-)-Pramipexole | 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)- | PRAMIPEXOLE | cid_119570
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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