Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 12
Ligand
BDBM60927
Substrate
n/a
Meas. Tech.
ChEMBL_1904592 (CHEMBL4406950)
IC50
>40000±n/a nM
Citation
 Lu, S; He, X; Ni, D; Zhang, J Allosteric Modulator Discovery: From Serendipity to Structure-Based Design. J Med Chem 62:6405-6421 (2019) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 12
Synonyms:
ERK6 | MAP kinase p38 gamma | MAPK12 | MK12_HUMAN | Mitogen-activated protein kinase 12 (MAPK12 p38 gamma) | Mitogen-activated protein kinase 12 (p38 gamma) | Mitogen-activated protein kinase 12 Gamma | Mitogen-activated protein kinase p38 gamma (p38 MAPKγ) | SAPK3 | p38 delta/gamma
Type:
Protein
Mol. Mass.:
41938.69
Organism:
Homo sapiens (Human)
Description:
P53778
Residue:
367
Sequence:
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL
  
Inhibitor
Name:
BDBM60927
Synonyms:
1-anilinonaphthalene-8-sulfonic acid | 8-Anilino-1-naphthalenesulfonic acid | ANS | Anilinonaphthalene-8-sulfonic acid (ANS) | BDBM50126831
Type:
n/a
Emp. Form.:
C16H13NO3S
Mol. Mass.:
299.344
SMILES:
OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12
Structure:
Search PDB for entries with ligand similarity: