Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM50528238
Substrate
n/a
Meas. Tech.
ChEMBL_1904670 (CHEMBL4407028)
IC50
0.200000±n/a nM
Citation
 Khan, I; Shareef, MA; Kumar, CG An overview on the synthetic and medicinal perspectives of indenopyrazoles. Eur J Med Chem 178:1-12 (2019) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50528238
Synonyms:
CHEMBL4453997
Type:
Small organic molecule
Emp. Form.:
C18H12N2O3
Mol. Mass.:
304.2995
SMILES:
COc1ccc(cc1)-c1n[nH]c2-c3cccc(C=O)c3C(=O)c12
Structure:
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