Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A
Ligand
BDBM50528405
Substrate
n/a
Meas. Tech.
ChEMBL_1904967 (CHEMBL4407325)
Kd
5900±n/a nM
Citation
 Yu, X; Huang, XP; Kenakin, TP; Slocum, ST; Chen, X; Martini, ML; Liu, J; Jin, J Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). J Med Chem 62:7557-7574 (2019) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50528405
Synonyms:
CHEMBL4449712
Type:
Small organic molecule
Emp. Form.:
C23H20FN5O2
Mol. Mass.:
417.4356
SMILES:
Nc1nc(NCc2ccc(Oc3ccccc3)cc2)nc(n1)-c1c(F)cccc1CO
Structure:
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