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Target
Adenosine receptor A2b
Ligand
BDBM50528497
Substrate
n/a
Meas. Tech.
ChEMBL_1905174 (CHEMBL4407532)
EC50
982±n/a nM
Citation
 Betti, M; Catarzi, D; Varano, F; Falsini, M; Varani, K; Vincenzi, F; Pasquini, S; di Cesare Mannelli, L; Ghelardini, C; Lucarini, E; Dal Ben, D; Spinaci, A; Bartolucci, G; Menicatti, M; Colotta, V Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. J Med Chem 62:6894-6912 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50528497
Synonyms:
CHEMBL4517597
Type:
Small organic molecule
Emp. Form.:
C20H14N4O2S2
Mol. Mass.:
406.481
SMILES:
COC(=O)c1cccc(CSc2nc(N)c(C#N)c(-c3cccs3)c2C#N)c1
Structure:
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