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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50528719
Substrate
n/a
Meas. Tech.
ChEMBL_1906146 (CHEMBL4408504)
EC50
1270±n/a nM
Citation
 Xue, Y; He, X; Yang, T; Wang, Y; Liu, Z; Zhang, G; Wang, Y; Wang, K; Zhang, L; Zhang, L Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50528719
Synonyms:
CHEMBL4475776
Type:
Small organic molecule
Emp. Form.:
C21H23N3O
Mol. Mass.:
333.4268
SMILES:
Cc1ccc2c(ccc3cc(cn23)C(=O)N[C@H]2CN3CCC2CC3)c1 |r,wD:16.17,(26.67,-22.08,;27.98,-21.35,;29.3,-22.14,;30.65,-21.38,;30.65,-19.83,;29.32,-19.06,;29.33,-17.52,;30.67,-16.76,;32,-17.54,;33.47,-17.08,;34.36,-18.33,;33.44,-19.57,;31.98,-19.08,;35.9,-18.35,;36.69,-17.03,;36.66,-19.7,;38.19,-19.72,;38.94,-21.07,;40.48,-21.09,;41.27,-19.77,;40.52,-18.43,;38.98,-18.41,;39.18,-19.72,;40.23,-19.88,;27.99,-19.81,)|
Structure:
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