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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50528720
Substrate
n/a
Meas. Tech.
ChEMBL_1906146 (CHEMBL4408504)
EC50
2000±n/a nM
Citation
 Xue, Y; He, X; Yang, T; Wang, Y; Liu, Z; Zhang, G; Wang, Y; Wang, K; Zhang, L; Zhang, L Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50528720
Synonyms:
CHEMBL4454650
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2
Mol. Mass.:
335.3996
SMILES:
Oc1ccc2c(ccc3cc(cn23)C(=O)N[C@H]2CN3CCC2CC3)c1 |r,wD:16.17,(5.59,-22.6,;6.9,-21.86,;8.22,-22.65,;9.57,-21.89,;9.57,-20.35,;8.24,-19.57,;8.25,-18.04,;9.59,-17.27,;10.92,-18.05,;12.39,-17.59,;13.28,-18.85,;12.36,-20.08,;10.9,-19.59,;14.82,-18.87,;15.61,-17.55,;15.58,-20.21,;17.12,-20.23,;17.86,-21.58,;19.4,-21.6,;20.19,-20.29,;19.44,-18.95,;17.9,-18.92,;18.1,-20.24,;19.16,-20.4,;6.91,-20.33,)|
Structure:
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