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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50528721
Substrate
n/a
Meas. Tech.
ChEMBL_1906146 (CHEMBL4408504)
EC50
8270±n/a nM
Citation
 Xue, Y; He, X; Yang, T; Wang, Y; Liu, Z; Zhang, G; Wang, Y; Wang, K; Zhang, L; Zhang, L Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50528721
Synonyms:
CHEMBL4438623
Type:
Small organic molecule
Emp. Form.:
C20H20FN3O
Mol. Mass.:
337.3907
SMILES:
Fc1ccc2c(ccc3cc(cn23)C(=O)N[C@H]2CN3CCC2CC3)c1 |r,wD:16.17,(26.18,-10.09,;27.49,-9.36,;28.81,-10.15,;30.15,-9.39,;30.16,-7.84,;28.83,-7.07,;28.84,-5.53,;30.18,-4.77,;31.51,-5.55,;32.98,-5.09,;33.87,-6.34,;32.95,-7.58,;31.49,-7.09,;35.41,-6.36,;36.2,-5.04,;36.17,-7.71,;37.7,-7.73,;38.45,-9.08,;39.99,-9.1,;40.77,-7.78,;40.03,-6.44,;38.49,-6.42,;38.69,-7.73,;39.74,-7.89,;27.5,-7.82,)|
Structure:
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