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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50528723
Substrate
n/a
Meas. Tech.
ChEMBL_1906146 (CHEMBL4408504)
EC50
7630±n/a nM
Citation
 Xue, Y; He, X; Yang, T; Wang, Y; Liu, Z; Zhang, G; Wang, Y; Wang, K; Zhang, L; Zhang, L Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50528723
Synonyms:
CHEMBL4527227
Type:
Small organic molecule
Emp. Form.:
C23H23N3O2
Mol. Mass.:
373.4476
SMILES:
O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc3cc(OCC#C)ccc3n2c1 |r,wD:3.2,(15.91,-40.66,;15.12,-41.98,;15.87,-43.32,;17.41,-43.34,;18.16,-44.69,;19.7,-44.72,;20.49,-43.4,;19.74,-42.06,;18.2,-42.03,;18.4,-43.35,;19.45,-43.51,;13.58,-41.96,;12.69,-40.7,;11.21,-41.16,;9.88,-40.38,;8.54,-41.15,;8.53,-42.68,;7.2,-43.44,;7.18,-44.97,;5.88,-45.71,;4.59,-44.94,;4.6,-43.44,;4.61,-41.94,;8.51,-45.76,;9.86,-45,;9.86,-43.46,;11.19,-42.7,;12.66,-43.19,)|
Structure:
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