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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50528724
Substrate
n/a
Meas. Tech.
ChEMBL_1906146 (CHEMBL4408504)
EC50
3200±n/a nM
Citation
 Xue, Y; He, X; Yang, T; Wang, Y; Liu, Z; Zhang, G; Wang, Y; Wang, K; Zhang, L; Zhang, L Discovery of fused heterocyclic carboxamide derivatives as novel ?7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50528724
Synonyms:
CHEMBL4473334
Type:
Small organic molecule
Emp. Form.:
C27H27N3O
Mol. Mass.:
409.5228
SMILES:
Cc1ccccc1-c1ccc2c(ccc3cc(cn23)C(=O)N[C@H]2CN3CCC2CC3)c1 |r,wD:22.24,(55.7,-18.01,;55.68,-19.52,;54.37,-20.25,;54.35,-21.76,;55.66,-22.53,;56.97,-21.79,;56.98,-20.29,;58.29,-19.55,;59.62,-20.34,;60.97,-19.58,;60.97,-18.03,;59.64,-17.25,;59.64,-15.71,;60.99,-14.94,;62.33,-15.73,;63.8,-15.27,;64.7,-16.53,;63.77,-17.77,;62.31,-17.27,;66.24,-16.55,;67.03,-15.22,;67,-17.9,;68.54,-17.91,;69.29,-19.27,;70.84,-19.29,;71.63,-17.97,;70.88,-16.62,;69.33,-16.6,;69.53,-17.92,;70.59,-18.08,;58.3,-18.01,)|
Structure:
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