Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50528970
Substrate
n/a
Meas. Tech.
ChEMBL_1906954 (CHEMBL4409312)
Ki
720±n/a nM
Citation
 Turnaturi, R; Chiechio, S; Salerno, L; Rescifina, A; Pittalą, V; Cantarella, G; Tomarchio, E; Parenti, C; Pasquinucci, L Progress in the development of more effective and safer analgesics for pain management. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50528970
Synonyms:
CHEMBL4522339
Type:
Small organic molecule
Emp. Form.:
C19H24N2O
Mol. Mass.:
296.4067
SMILES:
CCC1CC2CC3C1N(C2)CCc1c3[nH]c2ccc(O)cc12 |TLB:2:7:13.12.11.10:5.4.9,THB:1:2:6.5:8.9,13:6:8.9:3.2,10:8:6.5:3.2|
Structure:
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