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Target
Target of rapamycin complex subunit LST8
Ligand
BDBM315477
Substrate
n/a
Meas. Tech.
ChEMBL_1908592 (CHEMBL4410950)
IC50
1.000000±n/a nM
Citation
 Ouvry, G; Clary, L; Tomas, L; Aurelly, M; Bonnary, L; Borde, E; Bouix-Peter, C; Chantalat, L; Defoin-Platel, C; Deret, S; Forissier, M; Harris, CS; Isabet, T; Lamy, L; Luzy, AP; Pascau, J; Soulet, C; Taddei, A; Taquet, N; Thoreau, E; Varvier, E; Vial, E; Hennequin, LF Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. ACS Med Chem Lett 10:1561-1567 (2019) [PubMed]  Article 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | GBL | Gable | LST8 | LST8_HUMAN | MLST8 | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Homo sapiens
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM315477
Synonyms:
US10172858, Table 1.1 | US10172858, Table 1.22
Type:
Small organic molecule
Emp. Form.:
C15H15N7O
Mol. Mass.:
309.3259
SMILES:
CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc12
Structure:
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