Target
Target of rapamycin complex subunit LST8
Ligand
BDBM50529396
Substrate
n/a
Meas. Tech.
ChEMBL_1908592 (CHEMBL4410950)
IC50
30±n/a nM
Citation
 Ouvry, GClary, LTomas, LAurelly, MBonnary, LBorde, EBouix-Peter, CChantalat, LDefoin-Platel, CDeret, SForissier, MHarris, CSIsabet, TLamy, LLuzy, APPascau, JSoulet, CTaddei, ATaquet, NThoreau, EVarvier, EVial, EHennequin, LF Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. ACS Med Chem Lett 10:1561-1567 (2019) [PubMed]  Article 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | GBL | Gable | LST8 | LST8_HUMAN | MLST8 | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Homo sapiens
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM50529396
Synonyms:
CHEMBL4538629
Type:
Small organic molecule
Emp. Form.:
C17H19N7O
Mol. Mass.:
337.3791
SMILES:
CCCCn1nc(-c2ccc3oc(N)nc3c2)c2c(C)nc(N)nc12
Structure:
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