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Target
Kappa-type opioid receptor
Ligand
BDBM50529507
Substrate
n/a
Meas. Tech.
ChEMBL_1908762 (CHEMBL4411120)
Ki
0.158489±n/a nM
Citation
 Long, DD; Armstrong, SR; Beattie, DT; Campbell, CB; Church, TJ; Colson, PJ; Dalziel, SM; Jacobsen, JR; Jiang, L; Obedencio, GP; Rapta, M; Saito, D; Stergiades, I; Tsuruda, PR; Van Dyke, PM; Vickery, RG Discovery of Axelopran (TD-1211): A Peripherally Restricted ?-Opioid Receptor Antagonist. ACS Med Chem Lett 10:1641-1647 (2019) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50529507
Synonyms:
CHEMBL3971059
Type:
Small organic molecule
Emp. Form.:
C27H42N4O2
Mol. Mass.:
454.648
SMILES:
CC(C)NC(=O)N(CCN1[C@H]2CC[C@@H]1C[C@@H](C2)c1cccc(c1)C(N)=O)CC1CCCCC1 |r|
Structure:
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