Target
Mu-type opioid receptor
Ligand
BDBM50529507
Substrate
n/a
Meas. Tech.
ChEMBL_1908760 (CHEMBL4411118)
Ki
0.199526±n/a nM
Citation
 Long, DDArmstrong, SRBeattie, DTCampbell, CBChurch, TJColson, PJDalziel, SMJacobsen, JRJiang, LObedencio, GPRapta, MSaito, DStergiades, ITsuruda, PRVan Dyke, PMVickery, RG Discovery of Axelopran (TD-1211): A Peripherally Restricted ?-Opioid Receptor Antagonist. ACS Med Chem Lett 10:1641-1647 (2019) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50529507
Synonyms:
CHEMBL3971059
Type:
Small organic molecule
Emp. Form.:
C27H42N4O2
Mol. Mass.:
454.648
SMILES:
CC(C)NC(=O)N(CCN1[C@H]2CC[C@@H]1C[C@@H](C2)c1cccc(c1)C(N)=O)CC1CCCCC1 |r|
Structure:
Search PDB for entries with ligand similarity: