Reaction Details Report a problem with these data
Target
Pleiotrophin
Ligand
BDBM50529728
Substrate
n/a
Meas. Tech.
ChEMBL_1909743 (CHEMBL4412189)
Kd
78±n/a nM
Citation
 Yao, W; Chen, M; Dou, X; Jin, H; Zhang, X; Zhu, Y; Sha, M; Liu, Z; Meng, X; Zhang, L; Zhu, S; Li, Z Unravel a neuroactive sHA sulfation pattern with neurogenesis activity by a library of defined oligosaccharides. Eur J Med Chem 163:583-596 (2019) [PubMed]  Article 
Target
Name:
Pleiotrophin
Synonyms:
HB-GAM | HBBM | HBGF-8 | HBNF | HBNF-1 | HBNF1 | Heparin-binding brain mitogen | Heparin-binding growth factor 8 | Heparin-binding growth-associated molecule | Heparin-binding neurite outgrowth-promoting factor | Heparin-binding neurite outgrowth-promoting factor 1 | NEGF1 | OSF-1 | Osteoblast-specific factor 1 | PTN | PTN_HUMAN
Type:
PROTEIN
Mol. Mass.:
18961.47
Organism:
Homo sapiens
Description:
ChEMBL_118949
Residue:
168
Sequence:
MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD
  
Inhibitor
Name:
BDBM50529728
Synonyms:
CHEMBL4540967
Type:
Small organic molecule
Emp. Form.:
C34H55N5O29S2
Mol. Mass.:
1061.947
SMILES:
[H][C@]1(O[C@@H]2O[C@H](C(O)=O)[C@@]([H])(O[C@@H]3O[C@H](COS(O)(=O)=O)[C@@H](O)[C@]([H])(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)[C@H]3NC(C)=O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H](OCCCCCCN=[N+]=[N-])[C@@H]1NC(C)=O |r|
Structure:
Search PDB for entries with ligand similarity: