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Target
Steroid hormone receptor ERR2
Ligand
BDBM50530066
Substrate
n/a
Meas. Tech.
ChEMBL_1911362 (CHEMBL4413808)
IC50
1017±n/a nM
Citation
 Kim, J; Song, J; Ji, HD; Yoo, EK; Lee, JE; Lee, SB; Oh, JM; Lee, S; Hwang, JS; Yoon, H; Kim, DS; Lee, SJ; Jeong, M; Lee, S; Kim, KH; Choi, HS; Lee, SW; Park, KG; Lee, IK; Kim, SH; Hwang, H; Jeon, YH; Chin, J; Cho, SJ Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-? Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem 62:1837-1858 (2019) [PubMed]  Article 
Target
Name:
Steroid hormone receptor ERR2
Synonyms:
ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 Beta
Type:
PROTEIN
Mol. Mass.:
48061.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_11254
Residue:
433
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM50530066
Synonyms:
CHEMBL4472718
Type:
Small organic molecule
Emp. Form.:
C29H36Cl2N2O
Mol. Mass.:
499.515
SMILES:
Cl.Cl.CN1CCN(CC1)c1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(C)cc1
Structure:
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