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Target
Casein kinase II subunit beta
Ligand
BDBM50530315
Substrate
n/a
Meas. Tech.
ChEMBL_1911741 (CHEMBL4414187)
IC50
1000±n/a nM
Citation
 Bestgen, B; Kufareva, I; Seetoh, W; Abell, C; Hartmann, RW; Abagyan, R; Le Borgne, M; Filhol, O; Cochet, C; Lomberget, T; Engel, M 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action. J Med Chem 62:1817-1836 (2019) [PubMed]  Article 
Target
Name:
Casein kinase II subunit beta
Synonyms:
CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2
Type:
Enzyme
Mol. Mass.:
24937.13
Organism:
Homo sapiens (Human)
Description:
P67870
Residue:
215
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
  
Inhibitor
Name:
BDBM50530315
Synonyms:
CHEMBL4520531
Type:
Small organic molecule
Emp. Form.:
C20H14N2O3S
Mol. Mass.:
362.402
SMILES:
OC(=O)c1ccc(Nc2nc(cs2)-c2ccc3ccccc3c2)cc1O
Structure:
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