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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50242349
Substrate
n/a
Meas. Tech.
ChEMBL_1912872 (CHEMBL4415455)
Ki
7632±n/a nM
Citation
 Yamada, S; Kawasaki, M; Fujihara, M; Watanabe, M; Takamura, Y; Takioku, M; Nishioka, H; Takeuchi, Y; Makishima, M; Motoyama, T; Ito, S; Tokiwa, H; Nakano, S; Kakuta, H Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening. J Med Chem 62:8809-8818 (2019) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50242349
Synonyms:
(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid | (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid | (all-Z)-5,8,11,14,17-eicosapentaenoic acid | 5,8,11,14,17-EICOSAPENTAENOIC ACID | 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid | CHEMBL460026 | EPA | ICOSAPENT ETHYL | Icosapent | Timnodonic acid | all-cis-icosa-5,8,11,14,17-pentaenoic acid | cis-5,8,11,14,17-eicosapentaenoic acid | cis-Delta(5,8,11,14,17)-eicosapentaenoic acid | omega-3-Eicosapentaenoic Acid | vascepa
Type:
Small organic molecule
Emp. Form.:
C20H30O2
Mol. Mass.:
302.451
SMILES:
CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Structure:
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