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Target
Sodium channel subunit beta-1
Ligand
BDBM50530539
Substrate
n/a
Meas. Tech.
ChEMBL_1913279 (CHEMBL4415862)
IC50
31±n/a nM
Citation
 Focken, T; Burford, K; Grimwood, ME; Zenova, A; Andrez, JC; Gong, W; Wilson, M; Taron, M; Decker, S; Lofstrand, V; Chowdhury, S; Shuart, N; Lin, S; Goodchild, SJ; Young, C; Soriano, M; Tari, PK; Waldbrook, M; Nelkenbrecher, K; Kwan, R; Lindgren, A; de Boer, G; Lee, S; Sojo, L; DeVita, RJ; Cohen, CJ; Wesolowski, SS; Johnson, JP; Dehnhardt, CM; Empfield, JR Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na J Med Chem 62:9618-9641 (2019) [PubMed]  Article 
Target
Name:
Sodium channel subunit beta-1
Synonyms:
SCN1B | SCN1B_HUMAN | Sodium channel subunit beta-1
Type:
PROTEIN
Mol. Mass.:
24696.80
Organism:
Homo sapiens
Description:
ChEMBL_119389
Residue:
218
Sequence:
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
  
Inhibitor
Name:
BDBM50530539
Synonyms:
CHEMBL4460028 | US11174268, Example 300
Type:
Small organic molecule
Emp. Form.:
C22H23F3N4O2S2
Mol. Mass.:
496.569
SMILES:
CC1(C)CCN1Cc1cccc(F)c1CNc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1
Structure:
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