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Target
Endothelin-1 receptor
Ligand
BDBM50085844
Substrate
n/a
Meas. Tech.
ChEMBL_63363 (CHEMBL676099)
IC50
51±n/a nM
Citation
 Astles, PC; Brown, TJ; Halley, F; Handscombe, CM; Harris, NV; Majid, TN; McCarthy, C; McLay, IM; Morley, A; Porter, B; Roach, AG; Sargent, C; Smith, C; Walsh, RJ Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives. J Med Chem 43:900-10 (2000) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50085844
Synonyms:
(2-Bromo-phenyl)-[2-cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-acetic acid (0.5H2O) | CHEMBL427117
Type:
Small organic molecule
Emp. Form.:
C20H14BrNO4S
Mol. Mass.:
444.298
SMILES:
OC(=O)C(Oc1cc(OCc2ccsc2)ccc1C#N)c1ccccc1Br
Structure:
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