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Target
Indolethylamine N-methyltransferase
Ligand
BDBM50530712
Substrate
n/a
Meas. Tech.
ChEMBL_1913773 (CHEMBL4416356)
IC50
3400±n/a nM
Citation
 Policarpo, RL; Decultot, L; May, E; Kuzmi?, P; Carlson, S; Huang, D; Chu, V; Wright, BA; Dhakshinamoorthy, S; Kannt, A; Rani, S; Dittakavi, S; Panarese, JD; Gaudet, R; Shair, MD High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide  J Med Chem 62:9837-9873 (2019) [PubMed]  Article 
Target
Name:
Indolethylamine N-methyltransferase
Synonyms:
Amine N-methyltransferase | Aromatic alkylamine N-methyltransferase | Arylamine N-methyltransferase | INMT | INMT_HUMAN | Indolamine N-methyltransferase
Type:
PROTEIN
Mol. Mass.:
28884.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333668
Residue:
263
Sequence:
MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCFIVARKKPGP
  
Inhibitor
Name:
BDBM50530712
Synonyms:
CHEMBL4591248
Type:
Small organic molecule
Emp. Form.:
C24H27N7O6
Mol. Mass.:
509.5145
SMILES:
N[C@@H](CC[C@@H](C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C#Cc1cccc(c1)C(N)=O)C(O)=O |r|
Structure:
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