Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM79215
Substrate
n/a
Meas. Tech.
ChEMBL_1975 (CHEMBL617580)
IC50
53±n/a nM
Citation
 Matzen, L; van Amsterdam, C; Rautenberg, W; Greiner, HE; Harting, J; Seyfried, CA; Böttcher, H 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem 43:1149-57 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT1D | 5-hydroxytryptamine receptor 1D | 5HT1D_RAT | Htr1d | Serotonin 1 (5-HT1) receptor | Serotonin 1B/1D receptor | Serotonin receptor 1D
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41551.75
Organism:
RAT
Description:
5-HT1D HTR1D RAT::P28565
Residue:
374
Sequence:
MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
  
Inhibitor
Name:
BDBM79215
Synonyms:
CHEMBL15928 | GR 127935 | GR 127935 hydrochloride hydrate | MLS002153332 | N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride | N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride | N-[4-methoxy-3-(4-methylpiperazino)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride | SMR001230745 | cid_11497466
Type:
Small organic molecule
Emp. Form.:
C29H31N5O3
Mol. Mass.:
497.5881
SMILES:
COc1ccc(NC(=O)c2ccc(cc2)-c2ccc(cc2C)-c2noc(C)n2)cc1N1CCN(C)CC1
Structure:
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