Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50531244
Substrate
n/a
Meas. Tech.
ChEMBL_1914610 (CHEMBL4417193)
IC50
18900±n/a nM
Citation
 Hou, JQ; Fan, CL; Pei, X; Zhang, PL; Deng, F; Jiang, WQ; Wang, GC; Zhang, XQ; Ye, WC; Wang, H Psiguadiols A-J, Rearranged Meroterpenoids as Potent PTP1B Inhibitors from  J Nat Prod 82:3267-3278 (2019) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50531244
Synonyms:
CHEMBL4472595
Type:
Small organic molecule
Emp. Form.:
C30H34O6
Mol. Mass.:
490.5874
SMILES:
[H][C@]12C[C@@]3(O)[C@H](C)CC[C@@H](C(C)C)C3=C[C@@]1(C)Oc1c(C=O)c(O)c(C=O)c(O)c1[C@H]2c1ccccc1 |r,c:14|
Structure:
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