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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50262987
Substrate
n/a
Meas. Tech.
ChEMBL_1914765 (CHEMBL4417348)
IC50
>100000±n/a nM
Citation
 McCullough, BS; Batsomboon, P; Hutchinson, KB; Dudley, GB; Barrios, AM Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. J Nat Prod 82:3386-3393 (2019) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50262987
Synonyms:
CHEMBL506661 | Illudalic acid
Type:
Small organic molecule
Emp. Form.:
C15H16O5
Mol. Mass.:
276.2845
SMILES:
CC1(C)Cc2c(C1)c1C(=O)OC(O)Cc1c(C=O)c2O
Structure:
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