Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50086932
Substrate
n/a
Meas. Tech.
ChEMBL_161563 (CHEMBL768926)
IC50
82.0±n/a nM
Citation
 Malamas, MSSredy, JMoxham, CKatz, AXu, WMcDevitt, RAdebayo, FOSawicki, DRSeestaller, LSullivan, DTaylor, JR Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties. J Med Chem 43:1293-310 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50086932
Synonyms:
2-(4'-(2-benzylbenzofuran-3-yl)-4-phenethoxybiphenyl-3-ylamino)acetic acid | CHEMBL284763 | [4''-(2-Benzyl-benzofuran-3-yl)-4-phenethyloxy-biphenyl-3-ylamino]-acetic acid | [4'-(2-Benzyl-benzofuran-3-yl)-4-phenethyloxy-biphenyl-3-ylamino]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C37H31NO4
Mol. Mass.:
553.6463
SMILES:
OC(=O)CNc1cc(ccc1OCCc1ccccc1)-c1ccc(cc1)-c1c(Cc2ccccc2)oc2ccccc12
Structure:
Search PDB for entries with ligand similarity: