Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50086975
Substrate
n/a
Meas. Tech.
ChEMBL_161563 (CHEMBL768926)
IC50
28±n/a nM
Citation
 Malamas, MS; Sredy, J; Moxham, C; Katz, A; Xu, W; McDevitt, R; Adebayo, FO; Sawicki, DR; Seestaller, L; Sullivan, D; Taylor, JR Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties. J Med Chem 43:1293-310 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50086975
Synonyms:
Benzothiophene derivative | CHEMBL25628 | [4-(2-Benzyl-benzo[b]thiophen-3-yl)-5'-bromo-3''-methoxy-[1,1':3',1'']terphenyl-4'-yloxy]-acetic acid | [4-(2-Benzyl-benzo[b]thiophen-3-yl)-5'-bromo-3''-methoxy-[1,1';3',1'']terphenyl-4'-yloxy]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C36H27BrO4S
Mol. Mass.:
635.566
SMILES:
COc1cccc(c1)-c1cc(cc(Br)c1OCC(O)=O)-c1ccc(cc1)-c1c(Cc2ccccc2)sc2ccccc12
Structure:
Search PDB for entries with ligand similarity: