Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50016777
Substrate
n/a
Meas. Tech.
ChEMBL_3753 (CHEMBL620753)
Ki
8.81±n/a nM
Citation
 Linnanen, T; Brisander, M; Unelius, L; Sundholm, G; Hacksell, U; Johansson, AM Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors. J Med Chem 43:1339-49 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50016777
Synonyms:
((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium | (8-Hydroxyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine | (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol ((R)-OH-DPAT) | 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol(8-OH-DPAT) | CHEMBL26998 | R-(+)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol
Type:
Small organic molecule
Emp. Form.:
C16H25NO
Mol. Mass.:
247.3758
SMILES:
CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
Structure:
Search PDB for entries with ligand similarity: