Reaction Details Report a problem with these data
Target
Mineralocorticoid receptor
Ligand
BDBM50531567
Substrate
n/a
Meas. Tech.
ChEMBL_1920455 (CHEMBL4423300)
IC50
100±n/a nM
Citation
 Granberg, KL; Yuan, ZQ; Lindmark, B; Edman, K; Kajanus, J; Hogner, A; Malmgren, M; O'Mahony, G; Nordqvist, A; Lindberg, J; Tångefjord, S; Kossenjans, M; Löfberg, C; Brånalt, J; Liu, D; Selmi, N; Nikitidis, G; Nordberg, P; Hayen, A; Aagaard, A; Hansson, E; Hermansson, M; Ivarsson, I; Jansson-Löfmark, R; Karlsson, U; Johansson, U; William-Olsson, L; Hartleib-Geschwindner, J; Bamberg, K Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. J Med Chem 62:1385-1406 (2019) [PubMed]  Article 
Target
Name:
Mineralocorticoid receptor
Synonyms:
MCR_RAT | MR | Mineralocorticoid Receptor (MR) | Mineralocorticoid receptor | Mlr | Nr3c2 | Nuclear receptor subfamily 3 group C member 2 | mineralocorticoid
Type:
Enzyme Catalytic Domain
Mol. Mass.:
106748.15
Organism:
RAT
Description:
mineralocorticoid 0 RAT::P22199
Residue:
981
Sequence:
METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK
  
Inhibitor
Name:
BDBM50531567
Synonyms:
CHEMBL4557032
Type:
Small organic molecule
Emp. Form.:
C18H15FN2O4
Mol. Mass.:
342.3211
SMILES:
C[C@H]1COc2cc(F)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1 |r|
Structure:
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