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Target
Kallikrein-7
Ligand
BDBM113069
Substrate
n/a
Meas. Tech.
ChEMBL_1921341 (CHEMBL4424186)
IC50
48±n/a nM
Citation
 White, GV; Edgar, EV; Holmes, DS; Lewell, XQ; Liddle, J; Polyakova, O; Smith, KJ; Thorpe, JH; Walker, AL; Wang, Y; Young, RJ; Hovnanian, A Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome. Bioorg Med Chem Lett 29:821-825 (2019) [PubMed]  Article 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM113069
Synonyms:
US9695194, 5
Type:
Small organic molecule
Emp. Form.:
C18H17NO5
Mol. Mass.:
327.3313
SMILES:
CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1OC
Structure:
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