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Target
Programmed cell death 1 ligand 1
Ligand
BDBM50532086
Substrate
n/a
Meas. Tech.
ChEMBL_1921853 (CHEMBL4424698)
Kd
3000000±n/a nM
Citation
 Perry, E; Mills, JJ; Zhao, B; Wang, F; Sun, Q; Christov, PP; Tarr, JC; Rietz, TA; Olejniczak, ET; Lee, T; Fesik, S Fragment-based screening of programmed death ligand 1 (PD-L1). Bioorg Med Chem Lett 29:786-790 (2019) [PubMed]  Article 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50532086
Synonyms:
CHEMBL4568037
Type:
Small organic molecule
Emp. Form.:
C15H18N4
Mol. Mass.:
254.3302
SMILES:
Cc1cc(Nc2ccc(cc2)N2CCCC2)ncn1
Structure:
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