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Target
3-oxoacyl-[acyl-carrier-protein] synthase 2
Ligand
BDBM214777
Substrate
n/a
Meas. Tech.
ChEMBL_1922590 (CHEMBL4425546)
Kd
107200±n/a nM
Citation
 Bommineni, GR; Kapilashrami, K; Cummings, JE; Lu, Y; Knudson, SE; Gu, C; Walker, SG; Slayden, RA; Tonge, PJ Thiolactomycin-Based Inhibitors of Bacterial ?-Ketoacyl-ACP Synthases with in Vivo Activity. J Med Chem 59:5377-90 (2016) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
Synonyms:
2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF
Type:
PROTEIN
Mol. Mass.:
42419.21
Organism:
Staphylococcus aureus
Description:
ChEMBL_100958
Residue:
403
Sequence:
VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
  
Inhibitor
Name:
BDBM214777
Synonyms:
TLM18
Type:
Small organic molecule
Emp. Form.:
C14H19N3O2S
Mol. Mass.:
293.385
SMILES:
C\C(C=C)=C/[C@@]1(C)SC(=O)C(CCCCN=[N+]=[N-])=C1O |r,c:17|
Structure:
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