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Target
Beta-2 adrenergic receptor
Ligand
BDBM25751
Substrate
n/a
Meas. Tech.
ChEMBL_1923009 (CHEMBL4425965)
Kd
33000±n/a nM
Citation
 Dickson, CJ; Hornak, V; Velez-Vega, C; McKay, DJ; Reilly, J; Sandham, DA; Shaw, D; Fairhurst, RA; Charlton, SJ; Sykes, DA; Pearlstein, RA; Duca, JS Uncoupling the Structure-Activity Relationships of ?2 Adrenergic Receptor Ligands from Membrane Binding. J Med Chem 59:5780-9 (2016) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM25751
Synonyms:
Bisoprolol | Bisoprolol fumarate | Concor | [2-hydroxy-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propyl](propan-2-yl)amine
Type:
Small organic molecule
Emp. Form.:
C18H31NO4
Mol. Mass.:
325.443
SMILES:
CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1
Structure:
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