Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50532380
Substrate
n/a
Meas. Tech.
ChEMBL_1923025 (CHEMBL4425981)
IC50
18200±n/a nM
Citation
Huttunen, KM; Gynther, M; Huttunen, J; Puris, E; Spicer, JA; Denny, WA A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells. J Med Chem 59:5740-51 (2016) [PubMed] Article More Info.:
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
Inhibitor
Name:
BDBM50532380
Synonyms:
CHEMBL4522605
Type:
Small organic molecule
Emp. Form.:
C32H25N7O5
Mol. Mass.:
587.5848
SMILES:
CNC(=O)COc1ccc(cc1)-c1c(C#N)c(NC(=O)c2cccc(C[C@H](N)C(O)=O)c2)n2c3ccccc3nc2c1C#N |r|
Structure:
