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Target
Cyclin-C
Ligand
BDBM50532619
Substrate
n/a
Meas. Tech.
ChEMBL_1923379 (CHEMBL4426335)
IC50
15±n/a nM
Citation
 Bergeron, P; Koehler, MF; Blackwood, EM; Bowman, K; Clark, K; Firestein, R; Kiefer, JR; Maskos, K; McCleland, ML; Orren, L; Ramaswamy, S; Salphati, L; Schmidt, S; Schneider, EV; Wu, J; Beresini, M Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8. ACS Med Chem Lett 7:595-600 (2016) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50532619
Synonyms:
CHEMBL4568245
Type:
Small organic molecule
Emp. Form.:
C24H33F3N8O
Mol. Mass.:
506.567
SMILES:
CCN1CCN(Cc2ccc(NC(=O)N[C@H]3CCN(C3)c3ccnc(NC)n3)cc2C(F)(F)F)CC1 |r|
Structure:
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